abstract：:To assess mercury exposure and potential risk, total mercury (THg-H) and methylmercury (MeHg-H) in hair were studied in 160 adults. The study group consisted of 60 individuals living in the north central coast of Venezuela. A section of the area was known to be contaminated with mercury from a chlor-alkali plant insta...

journal_title：Investigacion clinica

authors： Rojas M,Nakamura K,Seijas D,Squiuante G,Pieters MA,Infante S

更新日期：2007-09-01 00:00:00

abstract：:IgA nephropathy (IgAN) is the most common glomerulonephritis in humans worldwide; its prevalence and prognosis vary according with geographical areas. The incidence is higher in adults under 30 years of age and in children, it occurs more frequently in patients between 3 and 10 years. Hematuria is the predominant mani...

journal_title：Investigacion clinica

authors： Coronel V,Mora-Orta S,Domínguez L,Corado J,Zibaoui PI,Bethencourt S,Weffer M,Pinto JA,Lara E,Orta N

更新日期：2007-06-01 00:00:00

abstract：:The objective of this study was to determine the experience of fluorosis and dental caries in 8- 12 year old children that drink water with different fluoride concentrations, from Maiquetía, Vargas State. Four hundred and twenty-one children were evaluated and divided in groups of 84 children each, according with thei...

journal_title：Investigacion clinica

authors： Montero M,Rojas-Sanchez F,Socorro M,Torres J,Acevedo AM

更新日期：2007-03-01 00:00:00

abstract：:During the last years, there has been a worldwide rise in the number of infectious diseases caused by newly discovered agents, in some cases and in others, by variants known as emergent or reemergent pathogens. The analysis of the nucleotide sequences of four RNA-positive hantaviruses (S. altoni) suggests that the Cañ...

journal_title：Investigacion clinica

authors： Valero N,Larreal Y

更新日期：2006-12-01 00:00:00

abstract：:A great variety of viruses which cause exanthema share other clinical manifestations, making etiologic identification relying exclusively on clinical examination a very difficult task. The most common agents include the measles virus, rubella, dengue, varicella, cytomegalovirus, Epstein Barr, enteroviruses, human parv...

journal_title：Investigacion clinica

authors： Valero N,Maldonado M

更新日期：2006-09-01 00:00:00

abstract：:The two biological characteristics that determine the malignancy of cancer are infiltration and metastasis. The study of these mechanisms is related to the invasion of tumoral cells and the relationship of these cells with their stroma, which interact producing the movement and accumulation of inflammatory cells, the ...

journal_title：Investigacion clinica

authors： Arvelo F,Cotte C

更新日期：2006-06-01 00:00:00

abstract：:To determine the global sleep quality and its components in patients of the Psychiatric Hospital of Maracaibo we performed a cross-sectional descriptive study based on a personal survey and the application of the Pittsburgh Sleep Quality Index (PSQI) in 57 individuals selected among all the 70 patients hospitalized in...

journal_title：Investigacion clinica

authors： Prieto-Rincón D,Echeto-Inciarte S,Faneite-Hernández P,Inciarte-Mundo J,Rincón-Prieto C,Bonilla E

更新日期：2006-03-01 00:00:00

abstract：:The yeasts of the Malassezia genus are part of the normal skin of man and other vertebrates. The description of new species for this genus has induced on their study in several countries. For this reason, is important to do research in order to get epidemiologic data about Malassezia species in tropical countries like...

journal_title：Investigacion clinica

authors： Rodríguez-Valero S,Mesa LM,Gonzalez-Morán E,Delmonte ML,Robertiz S,Valero A

更新日期：2005-12-01 00:00:00

abstract：:Human mortality due to envenomation by animals in Monagas state, Venezuela was evaluated. In this state 47 deaths due to envenomations produced by vertebrates and invertebrates (scorpions = 21, snakes = 20, bees = 6) during the period 1980-2000 were registered. The mountainous area, at the north of the state (Turimiqu...

journal_title：Investigacion clinica

authors： De Sousa L,Vásquez D,Salazar D,Valecillos R,Vásquez D,Rojas M,Parrila-Alvarez P,Quiroga M

更新日期：2005-09-01 00:00:00

abstract：:The increase of plasmatic homocysteine (Hc) in pregnant women, who later develop preeclampsia/eclampsia, the cause of this increment and its pathogenic role in toxemia of pregnancy, are still controversial. The objectives of the present research were to determine the plasmatic He concentrations during the first and se...

journal_title：Investigacion clinica

authors： Fernández M,Fernández G,Diez-Ewald M,Torres E,Vizcaíno G,Fernández N,Narváez J,Arteaga-Vizcaíno M

更新日期：2005-06-01 00:00:00

abstract：:Little information is available about Flavivirus infection in amerindian populations in western Venezuela. On this account the activity and seroprevalence of these viruses were determined and the hypothesis concerning the existence of a sylvatic cycle, conditioning the infection transmission of these viruses in indige...

journal_title：Investigacion clinica

authors： Valero N,Espina LM,Estévez J,Meleán E,Larreal Y,Maldonado M,Arias J,Añez G,Añez F,Pirela J

更新日期：2004-12-01 00:00:00

abstract：:The mental health of hemophilic individuals and their families play an important role on the integral treatment of the disease. The knowledge of the beliefs and attitudes perceived by the patients toward their disease will make possible a positive influence in their clinical improvement, their response to the treatmen...

journal_title：Investigacion clinica

authors： Carruyo-Vizcaíno C,Vizcaíno G,Carrizo E,Arteaga-Vizcaíno M,Sarmiento S,Vizcaíno-Carruyo J

更新日期：2004-09-01 00:00:00

abstract：:Classic pathology textbooks claim that acute splenitis reflects septic states, nevertheless, the evidence upon which that association is based remains unclear. We assessed the occurrence of acute splenitis, as an indicator of systemic infection, in 34 autopsies performed in patients in whom the cause of death was due ...

journal_title：Investigacion clinica

authors： Arismendi-Morillo GJ,Briceño-García AE,Romero-Amaro ZR,Fernández-Abreu MC,Girón-Piña HE

更新日期：2004-06-01 00:00:00

abstract：:Hypertrophic cardiomyopathy (HCM) is an autosomal dominant disease, which may afflict as many as 1 in 500 subjects (0.2%), being probably the most common hereditary cardiovascular disease and the most common cause of sudden cardiac death (SCD). Hypertrophic cardiomyopathy is characterized by the presence of unexplaine...

journal_title：Investigacion clinica

authors： Ramírez CD,Padrón R

更新日期：2004-03-01 00:00:00

abstract：:In Venezuela the yellow fever has been presented in three wild focuses: San Camilo in the Tachira State, South of the Lake in the Zulia and Guayana. The last human case registered of urban yellow fever happened in 1918 in the city of Coro, Falcon State. Nevertheless, according to the epidemic registration of the Minis...

journal_title：Investigacion clinica

authors： Valero N

更新日期：2003-12-01 00:00:00

abstract：:Dengue virus (DV) is responsible for a spectrum of diseases, from a self-limited fever disease (DF, dengue fever) to the more severe forms of hemorrhagic fever/dengue shock syndrome (DHF/DSS). The aim of this study was the serological and molecular confirmation of an outbreak of dengue in Falcon state, Venezuela. A to...

journal_title：Investigacion clinica

authors： Moros ZC,Abad MJ,Arsenak M,Martínez D,Cierco MM,Costagliola A,Urbina L,Taylor P,Liprandi F,Pujol FH

更新日期：2003-09-01 00:00:00

abstract：:The diagnostic of T. gondii infection is one of the most interesting features of the disease for investigators, since parasitological diagnostic is difficult to reach in the early period of the infection. The diagnostic is exclusively based in the detection of serum specific antibodies (IgG, IgM, IgA, IgE) and more re...

journal_title：Investigacion clinica

authors： Díaz-Suárez O

更新日期：2003-06-01 00:00:00

abstract：:The purpose of the present work was to determine the plasma concentrations of fibrinogen and Von Willebrand Factor (VWF) as well as platelet aggregation, in an apparently healthy population of 306 men and 41 women, 33 to 65 years of age, workers of the national oil industry (PDVSA, Maracaibo), as a base investigation ...

journal_title：Investigacion clinica

authors： Diez-Ewald M,Campos G,Rivero F,Alvarez L,Torres E,Arocha-Piñango CL,Ryder E,Arteaga-Vizcaíno M,Vizcaíno G,Fernández N

更新日期：2003-03-01 00:00:00

abstract：:The purpose of this study was to identify and to evaluate the psychosocial factors that produce organizational stress in workers at the packing plant of a brewering industry, and to determine the influence of industrial noise in the occurrence of stress at work. The Questionnaire of Organizational Stress of the ILO/WH...

journal_title：Investigacion clinica

authors： Chacín-Almarza B,Corzo-Alvarez G,Rojas-González L,Rodríguez-Chacín E,Corzo-Ríos G

更新日期：2002-12-01 00:00:00

abstract：:Mucormycosis is an acute and often fatal infection caused by a fungus of the Mucorales order of the Zygomycetes class. There are various clinical types, usually associated with an underlying disorder. The rhinocerebral mucormycosis is usually seen in diabetics, especially in ketoacidosis, but may also appear in health...

journal_title：Investigacion clinica

authors： Tristano A,Chollet ME,Willson M,Troccoli M

更新日期：2002-09-01 00:00:00

abstract：:The present transversal study was carried out to estimate the prevalence of both vitamin A deficiency (VAD) and protein-energy malnutrition among children (24 to 85 months) from three urban slums (n = 173) in Maracaibo city, Zulia State, Venezuela and a rural slum area (n = 34), vieinal to Maracaibo, by measuring seru...

journal_title：Investigacion clinica

authors： Amaya-Castellanos D,Viloria-Castejón H,Ortega P,Gómez G,Urrieta JR,Lobo P,Estévez J

更新日期：2002-06-01 00:00:00

abstract：:Local statistics report a great number of cases of neurological diseases of unidentified cause. The purpose of this research was to determine the presence of viral agents in patients with affection of the central nervous system, in Zulia State, Venezuela. In different health centers throughout the state, we collected ...

journal_title：Investigacion clinica

authors： Valero N,Henríquez R,Hernández C,Pomeda O,Romero M,Urdaneta F,Atencio R,Larreal Y,Espina LM,Rodríguez Z

更新日期：2001-12-01 00:00:00

abstract：:The fibrolipoma is a benign tumor variant of the lipoma, characterized by the presence of adipose and fibrous tissues. The authors report a case of a big oral fibrolipoma in a 72 year old woman. After surgery, a mass of 13 x 8 x 6 cm was obtained. The tumor had an implantation pedicle of 1 cm, on the floor of the mout...

journal_title：Investigacion clinica

authors： Oliveros-Chaparro C,Bogarin-Rodríguez J,Sánchez-Méndez M

更新日期：2001-06-01 00:00:00

abstract：:We report two patients with trisomy 21 whose karyotypes revealed unusual translocations. In the first case there was a tandem translocation with two chromosomes 21 attached to the long arm of chromosome 10 (45,XX + tan(10:21;21). In the second case there was an inverted tandem translocation between two chromosomes 21 ...

journal_title：Investigacion clinica

authors： Sánchez O,de Marade S,Guerra D

更新日期：2001-03-01 00:00:00

abstract：:Morphometry is a method to detect changes in a variety of tissues through quantitative elements. The purpose of this study was to examine several nuclear morphologic characteristics in normal and neoplastic mammary ductal cells using a multivariable method and expression of estrogen receptors by immunohistochemical te...

journal_title：Investigacion clinica

authors： Parada D,Farías RM,García-Tamayo J

更新日期：1999-12-01 00:00:00

abstract：:This study is the first report made in Venezuela concerning the ultrastructural characteristics of Ehrlichia sp in mononuclear blood cells from an experimentally infected dog. The animal developed clinical manifestations characteristic of the infection, and typical intracitoplasmic inclusion bodies were clearly seen i...

journal_title：Investigacion clinica

authors： Gutiérrez N,Martínez M,Arraga-Alvarado C,Bretaña A,Pacheco I,Comach G

更新日期：1999-09-01 00:00:00

abstract：:A soluble fraction from human frontal cortex with molecular weight less than 10 kD was tested for the presence of endogenous substances capable of modulating the [3H]-QNB binding to crude P1 + P2 fractions from the same region. The soluble fraction was able to decrease [3H]-QNB binding in a dose-response manner with a...

journal_title：Investigacion clinica

authors： Loureiro-Dos Santos NE,Rodríguez-Valenzuela CS,Bonfante-Cabarcas RA,Pascuzzo-Lima C,Moreno-Yanes JA

更新日期：1999-06-01 00:00:00

abstract：:In the Caracas Longitudinal Study, the canalization of 24 girls that started follow-up at age 4, 43 at age 8, and 32 at age 12 in: height (H), weight (W), Body Mass Index (BMI), cholesterol (CHOL), triglycerides (TG) and glucose (GL), was studied using Schneiderman n Tracking Index (TI) and age to age correlations. TI...

journal_title：Investigacion clinica

authors： Moya-Sifontes MZ,López-Blanco M,Bosch V,Cevallos JL

更新日期：1999-03-01 00:00:00

abstract：:Fluorescent in situ hybridization (FISH) is a rapid, sensitive and reliable method for the identification of complete chromosomes, or segments of them, during metaphase or nuclear interphase. The present study shows the results of the analysis of 32 bone marrow aspirates from patients with malignant hematological dise...

journal_title：Investigacion clinica

authors： Soto-Quintana M,Rojas-Atencio A,Chirino H,Alvarez-Nava F,Pineda-Del Villar L,Urdaneta K,González-Ferrer S,González R

更新日期：1998-06-01 00:00:00

abstract：:Far as it is known to us, there is only one report in the medical literature dealing with the teratogenous effect of vanadium on neural structures (1): while trying to experimentally induce anencephaly in the offsprings of swiss-albino mice through the administration of ammonium metavanadate via drinking water, during...

journal_title：Investigacion clinica

authors： Cardozo J

更新日期：1998-04-01 00:00:00

abstract：:An estimated 20% of all breast cancer or ovarian and breast cancer cases have familial aggregation. Today it is known that approximately 10% of these cases are attributable to inherited mutations of a predisposition gene that confers a high risk of developing the disease. Several genes have been identified that differ...

journal_title：Investigacion clinica

authors： Pineda-Del Villar L

更新日期：1998-03-01 00:00:00

abstract：:The results of examining in the course of the past twenty years a considerable number of malignant tumors with transmission electron microscopy and immunohistochemistry are discussed. The neoplasms were divided into epithelial tumors, tumors of fusiform cells, malignant round cell tumors and tumors of endocrine nature...

journal_title：Investigacion clinica

authors： García-Tamayo J,Caleiras E,Blasco-Olaetxea E,Parada D,de García SE

更新日期：1997-12-01 00:00:00

abstract：:Hypertension is a major risk factor for stroke/myocardial infarction as expression of the atherogenic process. Platelets play a fundamental role in all these disease processes. In physiological conditions there is an equilibrium between pro aggregating and anti aggregating factors. In pathological situations this equi...

journal_title：Investigacion clinica

authors： Hernández Hernández R,Carvajal AR,Armas de Hernández MJ,Armas Padilla MC

更新日期：1997-11-01 00:00:00

abstract：:Cystic Fibrosis (CF) is a severe and relatively common autosomic recessive disease caused by a variety of mutations in the CFTR gene. The most frequent mutation worldwide, consists of the deletion of the phenylalanine codon at position 508 (delta F508). Here we report the first cases of prenatal diagnosis of CF by DNA...

journal_title：Investigacion clinica

authors： Morales-Machín A,Borjas-Fajardo L,Pineda-Del Villar L,Prieto-Carrasquero M,González S,Gutiérrez M,Delgado-Luengo W,Alvarez F,Barrera-Saldaña H

更新日期：1997-09-01 00:00:00

abstract：:The allosteric behaviour of the p-nitrophenyl-phosphatase (E.C.3.1.3.1.) from membrane erythrocytes was investigated in the following multisystemic diseases: myotonic dystrophy, limb-girdle muscular dystrophy, Charcot-Marie-Tooth and juvenile spinal muscular atrophy; in myotonia congenita, which is not a multisystemic...

journal_title：Investigacion clinica

authors： Goldemberg AL,Madrid EA,García AM,Roubicek M,Esteban Trucco R

更新日期：1996-12-01 00:00:00

abstract：:Our study describes the presence of antineutrophil cytoplasmic antibodies (ANCA) in a group of different pathologies comprising 101 patients. Rheumatoid arthritis, systemic lupus erithematosus, idiopatic neutropenia, acute post-streptoccocal glomerulonephritis, minimal change nephrotic syndrome, Downs syndrome, adult ...

journal_title：Investigacion clinica

authors： Novo E,García-Mac Gregor E,Weir-Medina J,Parra G,Ocando A,Viera N

更新日期：1996-06-01 00:00:00

abstract：:Human ehrlichiosis is a zoonotic disease, caused by a rickettsia that infects leukocytes. It was described for the first time in the United States of America in 1986. More than 300 cases have been reported in that country. One case has been reported in Portugal, two in France and one more in a tourist coming from Mali...

journal_title：Investigacion clinica

authors： Arraga-Alvarado C,Montero-Ojeda M,Bernardoni A,Anderson BE,Parra O

更新日期：1996-03-01 00:00:00

abstract：:Stroke, the 5th. cause of death in Venezuela, has been associated to cerebral infarction. However, there is little information concerning lethality factors. 33 atherothrombotic subtype stroke patients, 31 (96%) Latino and 2(4%) white, were admitted into a prospective study to analyze the role of 11 mortality risk fact...

journal_title：Investigacion clinica

authors： Poni E,Granero R,Escobar B

更新日期：1995-12-01 00:00:00

abstract：:The Medical Genetics Unit at Universidad del Zulia (UGM-LUZ) gives counsel to patients with partial and total genetic diseases. Counseling is available for patients of both sexes and all ages, from public and private health centers and several medical specialities. In the present study an analysis of 4617 clinical rec...

journal_title：Investigacion clinica

authors： González-Ferrer S,Pineda-Del Villar L,Brito-Brito J,Prieto-Carrasquero M,Rojas-Atencio A,Angarita-Avila L,Mena-González JC,Mena-González R,Bermúdez J,Martínez-Basalo M

更新日期：1995-06-01 00:00:00

abstract：:In a group of 337 patients with a history of thrombotic episodes, pregnancy losses and/or thrombocytopenia, 66 cases of lupus anticoagulant (LA) were found. Spontaneous platelet aggregation and the aggregatory responses of platelet rich plasmas (PRP) from 14 patients, with a history of thrombotic episodes, with antica...

journal_title：Investigacion clinica

authors： Diez-Ewald M,Torres-Guerra E,Vizcaíno G,Arteaga-Vizcaíno M

更新日期：1995-03-01 00:00:00